书籍 For Blood and Money的封面

For Blood and Money

Nathan Vardi

出版时间

2023-01-10

ISBN

9780393540956

评分

★★★★★
书籍介绍
A gripping business narrative and scientific thriller about what it takes to bring a wonder drug to market―and save countless lives. For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug, and how the core team―denied their share of the profits―went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time. In the multibillion-dollar business of biotech, where pharmaceutical companies, the government, hedge funds, and venture capitalists have spent billions on funding, experimentation, and treatments, a single molecule can stop cancer in its tracks―and make the people who find that rare molecule astonishingly rich. For Blood and Money follows a small team at a biotech start-up in California, who have found one of these rare molecules. Their compound, known as a BTK inhibitor, seems to work on a vicious type of leukemia. When patients start rising from their hospice beds, the team knows they’re onto something big. What follows is a story of genius, pathos, and drama, in which vivid characters navigate a world of corporate intrigue and ambiguous morality. Vardi’s narrative immerses readers in the recent explosion of biotech start-ups. He describes the scientists, doctors, and investors who are risking everything to develop new, life-saving treatments, and introduces suffering patients for whom the stakes are life-or-death. A gripping nonfiction read, For Blood and Money illustrates why it’s so hard to bring new drugs to market, explains why they are so expensive, and examines how profit-driven venture capitalists are shaping the future of medicine.
用户评论
书写得精彩、故事跌宕起伏,如果非要说缺点可能还是记者常见的靠采访而不是分析和数据驱动
医药行业投资“教科书”,现代药物研发记。跟《十亿美元分子》比起来稍显逊色
riveting !!! 甚至已经想好了谁来演Bob Duggan 原来神秘license in康方bispecific背后大佬的故事是这样… 真是一个传奇 全球药物研发联系好紧密
這本非虛構作品比驚悚小説還要跌宕起伏。裏面人物出出進進,對新藥的開發也是做到了非常詳盡的描述,隨著時間的推進,一條綫分叉成了兩條綫,彼此的交集,競爭,人員的流動等等,作者在描寫的時候都照顧得非常周到,所以對作者做的詳盡的research深感欽佩。更爲重要的是,作者的口氣始終是非常中立的,沒有帶入自己的意見。很是感嘆一隻新藥的推出是多麽的不易,從最初科學家,化學家的想法,到最後能讓患者受益之間的周折,簡直無法想象。
非常值得一读 从insider的角度看整个biomedical行业
典型的记者写出来的故事会纪实小说,当小说看看可以,但是想要获得一些关于医药行业有用的insights,只能看个人功夫了
This book reads like an ultra-long news article — it’s packed with action yet rarely goes beyond the players involved in this very specific story to offer more insight on how they shape the way society works at large.
跟讲mRNA疫苗研发的那本书(A Shot to Save the World)很像啊,创新药的一大模式就是创业公司搞一半,然后卖给大公司,创业公司之间和大公司之间都在竞争。
超级好看。最精彩的两个人物Duggan和Rothbaum都是奇怪的狠人。biotech公司做新药研发其实真的像书里写的那样跌宕起伏。它是人,科学和资本的猛烈碰撞,如果成功,可以挽救千万性命,造福人类,也可以创造巨额财富。但风险巨大,早期BTK研发中的种种辗转,如果一个岔路走错,恐怕都不是今天的结果。书中讲的两个BTK抑制剂最开始都相当于白捡的。第一个是celera白给pharmacyclics的,另一个merck卖给acerta只收了1000刀。令人脑壳炸裂。
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